To explore the biochemical causes of mood modification due to nutritional compounds. Understanding the biochemistry will allow alternative health care practitioners to support their patients and themselves with food, supplements and/or herbs to address the possible dietary deficiencies that can lead to challenges with mood. There is a correlation between diet and mental/emotional health. Eating a healthy and nutritious diet, combined with wellness nutritional support may mitigate the dietary deficiencies that can lead to mood imbalances. Avoiding herb/drug and/or supplement/drug interactions will allow practitioners to safely provide individualized nutritional counseling to support their patients and/or themselves. Additionally, herbs and supplements that are contraindicated for patients who are medicated for mood disorders will be enumerated.